by Sandrine Pageau, Hans Rosenberg, Krishan Yadav | Apr 14, 2025 | Featured, Journal Club, Neurology
Methodology: 5/5 Usefulness: 4/5 Goyal M, et al. N Engl J Med. 2025 Feb 5. doi: 10.1056/NEJMoa2411668. Question and Methods: This multi-center, open label RCT of 530 patients presenting with medium-sized vessel stroke within 12h of last seen well compared functional...
by Courtney Price, Hans Rosenberg, Krishan Yadav | Jan 27, 2025 | Full Article, Journal Club, Neurology, Neurosurgery, Thrombosis
Methodology 3/5 Usefulness 3/5 Connolly SJ, et al. N Engl J Med. 2024 May 16;390(19):1745-1755. Editorial: Reversing Oral Anticoagulation in Intracerebral Hemorrhage. Question and Methods: This unblinded, multicentre randomized controlled trial studied whether...
by Eusang Ahn | Sep 26, 2024 | Commentary, Critical Care, Featured, Neurology, pharmacology, Resuscitation
I wrote this piece because understanding diseases by framing them as high or low levels of dopamine, acetylcholine, glutamate, or GABA has significantly improved my grasp of their pathophysiology and treatment strategies. Too often, medicine is taught as isolated...
by Josee Malette, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | May 20, 2024 | Full Article, Journal Club, Neurology
Methodology: 3/5 Usefulness: 2/5 Fischer U, et al. N Engl J Med. 2023 Jun 29;388(26):2411-2421. Question and Methods: RCT at 103 sites to compare outcomes at 30 days for early versus late DOAC initiation among patients with ischemic stroke and atrial fibrillation....
by Maria Berliant, Hans Rosenberg, Christian Vaillancourt | May 6, 2024 | Featured, Full Article, Journal Club, Neurology
Methodology: 4/5 Usefulness: 3/5 Zi W, et al. N Engl J Med. 2023 Jun 1;388(22):2025-2036. Editorial: Expanding Treatment for Acute Ischemic Stroke beyond Revascularization. Question and Methods: This multi-centre, triple-blind, double dummy RCT in China aimed to...
by Maria Berliant | Apr 11, 2024 | Featured, Grand Round Summaries, Neurology, psychiatry, Recently Featured
Note: This grand rounds presentation and summary had contributions from Dr. Anne-Marie Abe, a neuropsychiatrist specializing in functional neurological disorders in Ottawa. Patients living with functional neurologic disorders (FND) have been deeply stigmatized...
by Kathleen O'Connell | Mar 14, 2024 | Critical Care, Featured, Grand Round Summaries, Neurology, Recently Featured, Resuscitation
Posterior circulation ischemia accounts for approximately 20-25% of all ischemic strokes and is a significant cause of patient disability. The diagnosis can be extremely challenging as findings are often not typically focal. Posterior strokes are misdiagnosed more...
by Amanda Mattice, Hans Rosenberg, Jeff Perry | Jan 22, 2024 | Journal Club, Neurology
Methodology: 3.5/5 Usefulness: 4/5 Friedman BW, et al. Neurology. 2023 Oct 3;101(14):e1448-e1454. Question and Methods: This double-blinded RCT of 209 patients presenting to the ED with moderate to severe migraines compared high- to low- dose dexamethasone (16 mg vs...
by Pascale King, Hans Rosenberg, Christian Vaillancourt | Jan 2, 2024 | Critical Care, Full Article, Journal Club, Neurology
Methodology: 4/5 Usefulness: 2/5 Liu L, et al. BMJ. 2023 Oct 9;383:e076448. Question: Do early vs delayed blood pressure management in patients with mild-moderate acute ischemic strokes decrease death or dependency at 90 days? Methods: Randomization to early (24 hrs)...
by Zach MacDonald | Nov 9, 2023 | Grand Round Summaries, Neurology
Your next patient is an 80-year-old male, who had been functioning well until about a month ago. He has a history of type II diabetes, hypertension, and dyslipidemia, and has been working full-time. Upon reading the triage note and assessing the patient, you discover...
