by Emma Ferguson, Courtney Price | Jan 5, 2023 | Featured, Grand Round Summaries, Neurology
While most strokes we see are ischemic in nature, 10% of stroke presentations are intracerebral hemorrhages (ICH) 1. However, unlike ischemic strokes that have clear and evolving pathways for treatments, novel treatments for spontaneous intracerebral hemorrhages...
by Emma Ferguson, Hans Rosenberg, Ian Stiell | Sep 26, 2022 | Journal Club, Neurology
Methodology: 4.5/5 Usefulness: 5/5 Menon BK, et al. Lancet. 2022 Jul 16;400(10347):161-169. doi: 10.1016/S0140-6736(22)01054-6. Question and Methods: This multicentre, open label, randomized control trial at 22 primary and comprehensive stroke centres across Canada...
by Emma Ferguson, Lucy Karp | Sep 1, 2022 | Featured, Neurology, Neurosurgery
Acute stroke care is integrated into emergency medicine in many emergency departments across Canada. Whether you are involved in acute stroke care through consultation with neurology or through tele-stroke, understanding the complications of acute stroke therapy and...
by Evelyn Tran, Hans Rosenberg, Jeff Perry | May 9, 2022 | Journal Club, Neurology
Methodology: 3/5 Usefulness: 2/5 Jovin TG, et al. Lancet. 2022 Jan 15;399(10321):249-258. doi: 10.1016/S0140-6736(21)01341-6. Editorial: Late thrombectomy for ischaemic stroke. Dippel D, et al. Lancet. 2022 Jan 15;399(10321):213-215. Question and Methods: This...
by Renee Bradley, Hans Rosenberg, Jeff Perry | May 2, 2022 | Critical Care, Journal Club, Neurology, Neurosurgery
Methodology: 4.5/5 Usefulness: 4/5 Post R, et al. Lancet. 2021 Jan 9;397(10269):112-118. doi: 10.1016/S0140-6736(20)32518-6. Question and Methods: This prospective, multicentre, randomized, controlled, open-label trial investigated whether administering TXA...
by Hans Rosenberg | Nov 7, 2021 | Featured, Journal Club, Neurology
Methodology: 2.5 5 Usefulness: 2.5/5 Grotta JC, et al. N Engl J Med. 2021 Sep 9;385(11):971-981. doi: 10.1056/NEJMoa2103879. Question and Methods: This study investigated if mobile stroke units (MSU) alter outcomes when compared to standard management by emergency...
by Hans Rosenberg | Oct 4, 2021 | Featured, Journal Club, Neurology
Methodology: 4/5 Usefulness: 4/5 Perry JJ, et al. BMJ. 2021 Feb 4;372:n49. doi: 10.1136/bmj.n49. Question and methods: This multicenter prospective cohort study validates the Canadian TIA Score and compares it to the ABCD2 and ABCD2i score to identify risk...
by Doran Drew, Josee Malette | May 27, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Addressing the Controversies Around Thrombolytic Therapy (tPA) In our previous blog post, we reviewed the formative literature supporting the currently used tPA time window. The figure below highlights a summary of the time windows investigated within each study and...
by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Review of the formative literature of our current tPA time window in Acute Ischemic Stroke After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...
by Hans Rosenberg | Mar 22, 2021 | Journal Club, Neurology
Methodology: 4/5 Usefulness: 3.5/5 Thomalla G, et al. Lancet. 2020 Nov 14;396(10262):1574-1584 Question and Methods: The authors evaluated the role of perfusion-imaging facilitated thrombolysis in strokes of unknown duration by way of a systematic review and...
