Methodology Score: 4/5 Usefulness Score: 4/5 Schüpke S, et al N Engl J Med. 2019 Oct 17;381(16):1524-1534. Editorial: Ticagrelor or Prasugrel in Acute Coronary Syndromes – The Winner Takes It All? Question and Methods: This open-label multicenter trial was the first head-to-head trial examining Ticagrelor vs Prasugrel as part ofRead More →
Methodology Score: 4/5 Usefulness Score: 4.5/5 Kearon C, et al. N Engl J Med. 2019 Nov 28;381(22):2125-2134 Question and Methods: the authors sought to demonstrate safety using a d-dimer cut-off of 1000ng/mL for low pre-test probability patients & a cut-off of 500ng/mL for moderate pre-test probability patients. Findings: Of 1325Read More →
Journal Club Summary Methodology Score: 4.5/5 Usefulness Score: 4.5 /5 van der Pol LM, et al. N Engl J Med. 2019 Mar 21;380(12):1139-1149 Question and Methods: Using a prospective cohort study of 510 pregnant women, the authors were trying to see whether an algorithm could safely diagnose PEs and avoidRead More →
Journal Club Summary Methodology: 2.5/5 Usefulness: 2/5 Connolly SJ, et al. N Engl J Med. 2019 Feb 7. Question and Methods: This was the first trial looking at clinical outcomes for reversal of factor Xa inhibitor anticoagulation in major bleeding episodes using the specific reversal agent, Andexanet alfa. It wasRead More →
Journal Club Summary Methodology: 4/5 Usefulness: 4/5 Kent AP, et al. J Am Coll Cardiol. 2018 Jul 17;72(3):255-267 Question and Methods: This was a post hoc analysis of the RE-LY trial examining the risk of NSAID use in patients receiving oral anticoagulation (OAC) for atrial fibrillation. Findings: NSAID use wasRead More →
There are a few specific arrhythmias that we encounter often in the ED that deserve a little bit more thought. Dr. Matthew Lipinski takes us through a few updates in the area beyond the routine basics. For other Grand Rounds Summaries please see our archives. Chronic Bundle Branch Block andRead More →
Journal Club Summary Reference: Van der Hulle T, et al. Lancet. 2017 Jul 15;390(10091):289-297. Methodology Score: 4/5 Usefulness Score: 3.5/5 Questions and Methods: This multicenter trial implemented the YEARS simplified algorithm for suspected PE at 12 Netherlands sites in over 3000 patients. Findings: The algorithm was safe (0.61% had VTE),Read More →