by Graham Wilson, Jeff Perry, Hans Rosenberg | Apr 4, 2022 | Full Article, Journal Club, Neurosurgery, Thrombosis, Trauma
Methodology: 3/5 Usefulness: 3/5 Grewal K, et al. CMAJ. 2021 Oct 12;193(40):E1561-E1567. Question and Methods: Retrospective cohort study evaluating risk of ICH post head injury in ED patients >65 years on warfarin or DOAC or no anticoagulant. Findings: Patients...
by Rebecca Seliga, Alex Coutin, Michael Kruse | Mar 3, 2022 | Cardiology, Featured, Grand Round Summaries, Thrombosis
You are working an urgent care shift and you access your ED electronic track-board to pick up the next patient waiting to be seen: You assign yourself to patient Smith, and notice a helpful comment from your triage nurse stating the patient’s name is Angela. You...
by Hans Rosenberg | Jul 8, 2021 | Journal Club, Thrombosis
Methodology: 3.5/5 Usefulness: 2/5 Xu K, et al. J Thromb Haemost. 2021 Apr 8. doi: 10.1111/jth.15337. Epub ahead of print. PMID: 33834620. Question and methods: The authors sought to develop a new, simplified clinical decision rule to exclude DVT using individual...
by Hans Rosenberg | May 31, 2021 | Journal Club, Respirology, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Couturaud F, et al. JAMA. 2021 Jan 5;325(1):59-68. Question and Methods: This study used a multicenter, cross-sectional methodology with prospective follow up to determine the rates of PE in 740 COPD patients using the rGeneva score....
by Doran Drew, Josee Malette | May 27, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Addressing the Controversies Around Thrombolytic Therapy (tPA) In our previous blog post, we reviewed the formative literature supporting the currently used tPA time window. The figure below highlights a summary of the time windows investigated within each study and...
by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Review of the formative literature of our current tPA time window in Acute Ischemic Stroke After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...
by Hans Rosenberg | May 10, 2021 | ENT, Featured, Journal Club, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Reuben A, et al. Ann Emerg Med. 2021 Feb 18:S0196-0644(20)31461-X. Question and Methods: This was a double-blind, randomized controlled trial comparing topical tranexamic acid to placebo in patients presenting to the ED with epistaxis...
by Jim Yang, Kaitlin Endres, Josee Malette | Nov 19, 2020 | Critical Care, Featured, Grand Round Summaries, Medical Education, Thrombosis
Pulmonary embolism is often a nebulous diagnosis with various nuances. COMMON: They affect 25-100 people per 100,000, or approximately 30,000 Canadians every year Potentially FATAL: 3rd most deadly cardiovascular disease, after Heart Attack and Stroke Associated with...
by Hans Rosenberg | Nov 16, 2020 | Critical Care, Journal Club, Resuscitation, Thrombosis, Trauma
Methodology: 4/5 Usefulness: 3.5/5 Baksaas-Aasen K, et al. Intensive Care Med. 2020 Oct 13. doi: 10.1007/s00134-020-06266-1. Question and Methods: Pragmatic, European, multi-center RCT comparing outcomes in trauma patients who received empiric massive transfusion...
by Hans Rosenberg | Mar 23, 2020 | Cardiology, Featured, Journal Club, Thrombosis
Methodology Score: 4/5 Usefulness Score: 4/5 Schüpke S, et al N Engl J Med. 2019 Oct 17;381(16):1524-1534. Editorial: Ticagrelor or Prasugrel in Acute Coronary Syndromes – The Winner Takes It All? Question and Methods: This open-label multicenter trial was the...
