by Alex Coutin, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Jul 17, 2023 | Featured, Full Article, Journal Club, Thrombosis
Methodology: 2/5 Usefulness: 1/5 Lim P, et al. Eur Heart J Acute Cardiovasc Care. 2022 Jan 12;11(1):2-9. Question and Methods: Does diuresis with single-dose IV furosemide improve hemodynamic parameters and prevent oligo-anuria in normotensive patients with...
by Hailey Newton, Hans Rosenberg, Jeff Perry | Jun 19, 2023 | Featured, Journal Club, Thrombosis, Trauma
Methodology: 4/5 Usefulness: 3.5/5 Bouzat P, et al. JAMA. 2023 Mar 21:e234080. doi: 10.1001/jama.2023.4080. Question and Methods: This double-blind, randomized, placebo-controlled superiority trial aimed to assess whether 4F-PCC decreases 24hr blood product...
by Rebecca Seliga, Alex Coutin, Michael Kruse | Jun 29, 2022 | Cardiology, Featured, Grand Round Summaries, Thrombosis
You are working an urgent care shift and you access your ED electronic track-board to pick up the next patient waiting to be seen: You assign yourself to patient Smith, and notice a helpful comment from your triage nurse stating the patient’s name is Angela. You...
by Graham Wilson, Jeff Perry, Hans Rosenberg | Apr 4, 2022 | Full Article, Journal Club, Neurosurgery, Thrombosis, Trauma
Methodology: 3/5 Usefulness: 3/5 Grewal K, et al. CMAJ. 2021 Oct 12;193(40):E1561-E1567. Question and Methods: Retrospective cohort study evaluating risk of ICH post head injury in ED patients >65 years on warfarin or DOAC or no anticoagulant. Findings: Patients...
by Hans Rosenberg | Jul 8, 2021 | Journal Club, Thrombosis
Methodology: 3.5/5 Usefulness: 2/5 Xu K, et al. J Thromb Haemost. 2021 Apr 8. doi: 10.1111/jth.15337. Epub ahead of print. PMID: 33834620. Question and methods: The authors sought to develop a new, simplified clinical decision rule to exclude DVT using individual...
by Hans Rosenberg | May 31, 2021 | Journal Club, Respirology, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Couturaud F, et al. JAMA. 2021 Jan 5;325(1):59-68. Question and Methods: This study used a multicenter, cross-sectional methodology with prospective follow up to determine the rates of PE in 740 COPD patients using the rGeneva score....
by Doran Drew, Josee Malette | May 27, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Addressing the Controversies Around Thrombolytic Therapy (tPA) In our previous blog post, we reviewed the formative literature supporting the currently used tPA time window. The figure below highlights a summary of the time windows investigated within each study and...
by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Review of the formative literature of our current tPA time window in Acute Ischemic Stroke After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...
by Hans Rosenberg | May 10, 2021 | ENT, Featured, Journal Club, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Reuben A, et al. Ann Emerg Med. 2021 Feb 18:S0196-0644(20)31461-X. Question and Methods: This was a double-blind, randomized controlled trial comparing topical tranexamic acid to placebo in patients presenting to the ED with epistaxis...
by Jim Yang, Kaitlin Endres, Josee Malette | Nov 19, 2020 | Critical Care, Featured, Grand Round Summaries, Medical Education, Thrombosis
Pulmonary embolism is often a nebulous diagnosis with various nuances. COMMON: They affect 25-100 people per 100,000, or approximately 30,000 Canadians every year Potentially FATAL: 3rd most deadly cardiovascular disease, after Heart Attack and Stroke Associated with...
