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The D-Dimer Dilemma: It’s Use In Low-Risk PE

The D-Dimer Dilemma: It’s Use In Low-Risk PE

by Jim Yang | Nov 19, 2020 | All Posts, Critical Care, Featured, Grand Round Summaries, Medical Education, Thrombosis

Pulmonary embolism is often a nebulous diagnosis with various nuances. COMMON: They affect 25-100 people per 100,000, or approximately 30,000 Canadians every year Potentially FATAL: 3rd most deadly cardiovascular disease, after Heart Attack and Stroke Associated with...
Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial

Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial

by Hans Rosenberg | Nov 16, 2020 | Critical Care, Journal Club, Resuscitation, Thrombosis, Trauma

Methodology: 4/5 Usefulness: 3.5/5 Baksaas-Aasen K, et al. Intensive Care Med. 2020 Oct 13. doi: 10.1007/s00134-020-06266-1.  Question and Methods: Pragmatic, European, multi-center RCT comparing outcomes in trauma patients who received empiric massive transfusion...
Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes

Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes

by Hans Rosenberg | Mar 23, 2020 | Cardiology, Featured, Journal Club, Thrombosis

Methodology Score: 4/5 Usefulness Score: 4/5 Schüpke S, et al N Engl J Med. 2019 Oct 17;381(16):1524-1534. Editorial: Ticagrelor or Prasugrel in Acute Coronary Syndromes – The Winner Takes It All? Question and Methods: This open-label multicenter trial was the...
Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability

Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability

by Hans Rosenberg | Feb 10, 2020 | Journal Club, landmark, Thrombosis

Methodology Score: 4/5 Usefulness Score: 4.5/5 Kearon C, et al. N Engl J Med. 2019 Nov 28;381(22):2125-2134 Question and Methods: the authors sought to demonstrate safety using a d-dimer cut-off of 1000ng/mL for low pre-test probability patients & a cut-off of...
Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism

Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism

by Hans Rosenberg | Aug 19, 2019 | Journal Club, OBGYN, Thrombosis

Journal Club Summary Methodology Score: 4.5/5 Usefulness Score: 4.5 /5 van der Pol LM, et al. N Engl J Med. 2019 Mar 21;380(12):1139-1149 Question and Methods: Using a prospective cohort study of 510 pregnant women, the authors were trying to see whether an algorithm...
Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

by Hans Rosenberg | May 13, 2019 | Journal Club, Thrombosis

Journal Club Summary Methodology: 2.5/5 Usefulness: 2/5 Connolly SJ, et al. N Engl J Med. 2019 Feb 7. Question and Methods: This was the first trial looking at clinical outcomes for reversal of factor Xa inhibitor anticoagulation in major bleeding episodes using the...
Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation

Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation

by Hans Rosenberg | Dec 17, 2018 | Featured, Journal Club, Thrombosis

Journal Club Summary Methodology: 4/5 Usefulness: 4/5 Kent AP, et al. J Am Coll Cardiol. 2018 Jul 17;72(3):255-267 Question and Methods: This was a post hoc analysis of the RE-LY trial examining the risk of NSAID use in patients receiving oral anticoagulation (OAC)...
My Heart is Racing! Select Cardiac Arrhythmias in the ED

My Heart is Racing! Select Cardiac Arrhythmias in the ED

by Rob Suttie | Feb 15, 2018 | cardiac arrest, Cardiology, Critical Care, Resuscitation, Thrombosis

There are a few specific arrhythmias that we encounter often in the ED that deserve a little bit more thought. Dr. Matthew Lipinski takes us through a few updates in the area beyond the routine basics. For other Grand Rounds Summaries please see our archives. Chronic...

Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study

by Hans Rosenberg | Oct 23, 2017 | Journal Club, landmark, Thrombosis

Journal Club Summary Reference: Van der Hulle T, et al. Lancet. 2017 Jul 15;390(10091):289-297.  Methodology Score: 4/5                   Usefulness Score: 3.5/5 Questions and Methods: This multicenter trial implemented the YEARS simplified algorithm for suspected PE...

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