tranexamic acid Archives

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomized, placebo-controlled trial

by Hans Rosenberg | Dec 9, 2019 | Full Article, Neurosurgery, Trauma

Methodology: 3.5/5 Usefulness: 3.5/5 The CRASH-3 trial collaborators. The Lancet. 2019 Oct 14. Online First Editorial: CRASH-3: a win for patients with traumatic brain injury Question and Methods: Multi-centre, randomized, placebo-controlled trial looking at whether...

Crashing through the snow, reviewing the CRASH-3 trial

by Krishan Yadav | Nov 7, 2019 | Featured, Journal Club, Trauma

Dr. Krishan Yadav is an FRCPC Emergency Medicine Physician with a Masters in Clinical Epidemiology, and here he helps to provide some great insights and opinions into the recently published CRASH-3 trial. Tranexamic Acid (TXA) TXA is an inexpensive and readily...

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

by Hans Rosenberg | Mar 18, 2019 | Critical Care, Full Article, Journal Club, landmark, Neurosurgery

Journal Club Methodology Score: 4/5 Usefulness Score: 3/5 Sprigg N, et al. Lancet. 2018 May 26;391(10135):2107-2115 Question and Methods: Multicenter, double-blinded, randomized, placebo-controlled trial comparing if IV TXA vs placebo, given within 8h of spontaneous...

Damage Control Resuscitation (DCR) – A Summary of the Joint Trauma System Clinical Practice Guideline

by Richard Hoang | Mar 7, 2019 | Critical Care, Featured, Pre-Hospital, Resuscitation, Trauma

Hemorrhage is the leading cause of preventable death on the battlefield. Damage Control Resuscitation (DCR) works synergistically with Damage Control Surgery (DCS) and prioritizes non-surgical interventions that reduce morbidity and mortality due to trauma and...

Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial

by emottawa | Aug 4, 2014 | Journal Club

Journal Club Summary Landmark Series Methodology Score: 4/5 Usefulness Score: 4/5 CRASH-2 trial collaborators Lancet. 2010 Jul 3;376(9734):23-32. Article Link This large RCT assessed the effect of early administration of tranexamic acid to trauma...