A non-inferiority randomized controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial

A non-inferiority randomized controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial

by , , | Dec 1, 2025 | Full Article, Gastroenterology, Journal Club, Toxicology

Methodology: 3.5/5 Usefulness: 4/5 Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Question and Methods: This multicentre unblinded RCT with 204 patients assessed non-inferiority of a 12-hour NAC protocol for single non-massive...
Comparing the efficacy of intravenous morphine versus ibuprofen or the combination of ibuprofen and acetaminophen in patients with closed limb fractures: a randomized clinical trial

Comparing the efficacy of intravenous morphine versus ibuprofen or the combination of ibuprofen and acetaminophen in patients with closed limb fractures: a randomized clinical trial

by , , | Jun 24, 2024 | Full Article, Journal Club, Trauma

Methodology: 3.5/5 Usefulness: 2/5 Nasr Isfahani M, et al. BMC Emerg Med. 2024 Jan 25;24(1):15.  Question and Methods: This triple blinded RCT of 158 patients with isolated closed limb fractures assessed pain scores at 1-hour following the administration of...