Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Methodology: 4.5/5 Usefulness: 5/5 Menon BK, et al. Lancet. 2022 Jul 16;400(10347):161-169. doi: 10.1016/S0140-6736(22)01054-6. Question and Methods: This multicentre, open label, randomized control trial at 22 primary and comprehensive stroke centres across Canada...
Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial

Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial

Methodology: 4/5 Usefulness: 3/5 Driver BE, et al. JAMA. 2021 Dec 28;326(24):2488-2497. Question and Methods:  Multicentre unblinded pragmatic trial comparing first pass success with the bougie compared to stylet in endotracheal intubation of critically ill patients ...
External validation of a low HEAR score to identify emergency department chest pain patients at very low risk of major adverse cardiac events without troponin testing

External validation of a low HEAR score to identify emergency department chest pain patients at very low risk of major adverse cardiac events without troponin testing

Methodology: 3.5/5 Usefulness: 2.5/5 O’Rielly CM, et al. CJEM. 2021 Jul 17. doi: 10.1007/s43678-021-00159-y. Question and Methods:  Secondary analysis validation study that sought to validate proposed HEAR score’ ability to identify low risk patients for acute...