EMOttawa Blog Archives

A non-inferiority randomized controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial

by Maria Berliant, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Dec 1, 2025 | Full Article, Gastroenterology, Journal Club, Toxicology

Methodology: 3.5/5 Usefulness: 4/5 Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Question and Methods: This multicentre unblinded RCT with 204 patients assessed non-inferiority of a 12-hour NAC protocol for single non-massive...

Optimal Head-of-Bed Positioning Before Thrombectomy in Large Vessel Occlusion Stroke: A Randomized Clinical Trial

by Faran Khalid, Hans Rosenberg, Ian Stiell | Nov 3, 2025 | Full Article, Journal Club, Neurology

Methodology: 3.5/5 Usefulness: 3.5/5 Alexandrov AW, et al. JAMA Neurol. 2025 Sep 1;82(9):905-914. doi: 10.1001/jamaneurol.2025.2253. Question and Methods: Authors aimed to determine if 0° head positioning reduces neurological deterioration and mortality in stroke...

Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy: The ANGEL-TNK Randomized Clinical Trial

by Kaitlin Endres, Hans Rosenberg, Ian Stiell | Oct 22, 2025 | Journal Club, Neurology

Methodology: 4.5/5 Usefulness: 4/5 Miao Z, et al. JAMA. 2025 Aug 19;334(7):582-591. doi: 10.1001/jama.2025.10800. Question and Methods: To compare clinical outcomes in patients with acute LVO for those who received intra-arterial tenecteplase after successful...

Multidose Ondansetron after Emergency Visits in Children with Gastroenteritis

by Samara Adler, Hans Rosenberg, Krishan Yadav | Sep 29, 2025 | Gastroenterology, Journal Club, Pediatrics

Freedman SB, et al. N Engl J Med. 2025 Jul 17;393(3):255-266. doi: 10.1056/NEJMoa2503596. Methodology: 4.5/5 Usefulness: 4/5 Question and Methods: This multicentre, double-blind randomized superiority trial evaluated the effectiveness of oral ondansetron dispensed at...

Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study

by Mathieu McKinnon, Hans Rosenberg, Jeff Perry | Aug 25, 2025 | Journal Club, Neurology, Pre-Hospital

Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X. Question and Methods: Double-blind, placebo-controlled RCT to determine if prehospital administration of nerinetide for suspected acute...