Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study

Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study

by , , | Aug 25, 2025 | Journal Club, Neurology, Pre-Hospital

Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X.  Question and Methods: Double-blind, placebo-controlled RCT to determine if prehospital administration of nerinetide for suspected acute...
Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial

Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial

by , , | Jul 14, 2025 | Cardiology, Full Article, Journal Club

Methodology: 4/5 Usefulness: 3.5/5 Miller J, et al. Ann Emerg Med. 2024 Oct;84(4):399-408. doi: 10.1016/j.annemergmed.2024.04.024.  Question and Methods: The Authors assessed whether a 0/1-hour high-sensitivity troponin protocol increased safe ED discharges compared...
Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

by , , | Jun 17, 2025 | Cardiology, Critical Care, Journal Club

Methodology: 4/5 Usefulness: 1/5 Thiele H, et al. Lancet. 2024 Sep 14;404(10457):1019-1028. doi: 10.1016/S0140-6736(24)01448-X Question and Methods: Does routine early use of mechanical circulatory support (MCS) reduce mortality in acute myocardial infarction...