emottawa journal club Archives

Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up

by Prince Asare-Agbo, Hans Rosenberg, Ian Stiell | Jun 17, 2025 | Cardiology, Critical Care, Journal Club

Methodology: 4/5 Usefulness: 1/5 Thiele H, et al. Lancet. 2024 Sep 14;404(10457):1019-1028. doi: 10.1016/S0140-6736(24)01448-X Question and Methods: Does routine early use of mechanical circulatory support (MCS) reduce mortality in acute myocardial infarction...

High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial

by Caitlin Hutchings, Hans Rosenberg, Ian Stiell | Jun 2, 2025 | Critical Care, Full Article, Respirology

Methodology: 3.5/5 Usefulness: 3/5 RENOVATE Investigators and the BRICNet Authors; et al. JAMA. 2025 Mar 11;333(10):875-890. doi: 10.1001/jama.2024.26244. Question and methods: This multicentre, adaptive, RCT aimed to demonstrate noninferiority of HFNO vs NIV in...

Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis

by Simranjeet Singh, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | May 12, 2025 | Gastroenterology, Journal Club, Ultrasound

Methodology: 4/5 Usefulness: 3.5/5 Wilson SJ, et al. Ann Emerg Med. 2024 Mar;83(3):235-246. doi: 10.1016/j.annemergmed.2023.09.005. Questions and Method: To determine the diagnostic accuracy of emergency physician performed point of care ultrasound (POCUS) for acute...

Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage

by Megan Brenkel, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | May 5, 2025 | Critical Care, Featured, Journal Club, Neurosurgery

Methodology: 4/5 Usefulness: 3/5 English SW, et al. N Engl J Med. 2025 Mar 13;392(11):1079-1088. doi: 10.1056/NEJMoa2410962. Question and Methods: This multicenter RCT assessed whether a liberal (Hgb≤100 g/L) versus restrictive (Hgb≤80 g/L) transfusion strategy...

Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial

by Nicholas Choi, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Apr 28, 2025 | Airway, Critical Care, Full Article, Journal Club, Respirology

Methodology: 3/5 Usefulness: 3/5 Luo Z, et al. JAMA. 2024;332(20):1709–1722. doi:10.1001/jama.2024.15815 Question and Methods: Multi-centre, randomized control trial to determine whether a high-intensity NIPPV strategy reduces the need for intubation in AECOPD...