Journal Club Archives - Page 2 of 29

Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding

by Hans Rosenberg | Dec 14, 2020 | Full Article, Gastroenterology, Journal Club, Resuscitation

Methodology: 3/5 Usefulness: 3.5/5 Lau JYW, et al. N Engl J Med. 2020 Apr 2;382(14):1299-1308. Question and Methods: Single centre RCT comparing whether urgent (<6h) endoscopy improved outcomes compared to early endoscopy (6-24h) in patients presenting with...

Blood Culture Results Before and After Antimicrobial Administration in Patients With Severe Manifestations of Sepsis: A Diagnostic Study

by Hans Rosenberg | Dec 7, 2020 | Critical Care, Featured, Infectious Disease, Journal Club

Methodology: 3.5/5 Usefulness: 3.5/5 Ann Intern Med. 2019 Oct 15;171(8):547-554. Cheng MP, et al. Question and Methods: Multi-center diagnostic study that investigated the sensitivity of post-antimicrobial blood cultures compared to pre-antimicrobial blood cultures in...

Viscoelastic haemostatic assay augmented protocols for major trauma haemorrhage (ITACTIC): a randomized, controlled trial

by Hans Rosenberg | Nov 16, 2020 | Critical Care, Journal Club, Resuscitation, Thrombosis, Trauma

Methodology: 4/5 Usefulness: 3.5/5 Baksaas-Aasen K, et al. Intensive Care Med. 2020 Oct 13. doi: 10.1007/s00134-020-06266-1. Question and Methods: Pragmatic, European, multi-center RCT comparing outcomes in trauma patients who received empiric massive transfusion...

Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.

by Hans Rosenberg | Nov 9, 2020 | Journal Club, Neurology

Methodology: 2/5 Usefulness: 2/5 Johnston SC, et al. N Engl J Med. 2020 Jul 16;383(3):207-217. Question and Methods: Multicentre, double-blind RCT of ASA vs Ticagrelor-ASA among 11016 patients with high-risk TIA or minor stroke for prevention of stroke/death within 30...

Association of Checklist Use in Endotracheal Intubation With Clinically Important Outcomes: A Systematic Review and Meta-analysis.

by Hans Rosenberg | Nov 2, 2020 | Anesthesiology, Full Article, Journal Club, Resuscitation

Methodology: 3.5/5 Usefulness: 2/5 Turner JS, et al. JAMA Netw Open. 2020 Jul 1;3(7):e209278. Question and Methods: Systematic review and meta-analysis evaluating if checklist use during endotracheal intubation leads to improved patient outcomes. Findings: The authors...

Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial

by Hans Rosenberg | Oct 5, 2020 | Addictions, Journal Club, Toxicology

Methodology: 3/5 Usefulness: 2/5 Anton RF, et al. JAMA Intern Med. 2020 Mar 9;180(5):1-9. Question and Methods: Blinded randomized control trial comparing gabapentin to placebo in reducing the number of heavy drinking days in alcohol use disorder treatment. Findings:...

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

by Hans Rosenberg | Sep 28, 2020 | Full Article, Gastroenterology, Journal Club

Methodology: 4/5 Usefulness: 4/5 HALT-IT Trial Collaborators. Lancet. 2020 Jun 20;395(10241):1927-1936 Questions and Methods: This was an international, randomized, double-blind, placebo-controlled trial with the objective to quantify the effect of TXA on death due to...

Musculoskeletal Ultrasonography to Diagnose Dislocated Shoulders: A Prospective Cohort

by Hans Rosenberg | Sep 23, 2020 | Featured, Journal Club, Orthopedics, Ultrasound

Methodology: 3/5 Usefulness: 3/5 Secko MA, et al. Ann Emerg Med. 2020 Aug;76(2):119-128. Question and Methods: Attempted to validated the use of a posterior PoCUS approach in diagnosing shoulder dislocations and assessing the adequacy of reduction in the ED...

Video Laryngoscopy Compared to Augmented Direct Laryngoscopy in Adult Emergency Department Tracheal Intubations: A National Emergency Airway Registry (NEAR) Study

by Hans Rosenberg | Aug 10, 2020 | Airway, Anesthesiology, Journal Club

Methodology: 2/5 Usefulness: 4/5 Brown CA 3rd, et al. Acad Emerg Med. 2020 Feb;27(2):100-108. Question and Methods: This was one the largest prospective, observational, ED-only airway studies to date comparing first-pass success (FPS) rates in “augmented” DL (A-DL)...

Does N-Terminal Pro-B-Type Natriuretic Peptide Improve the Risk Stratification of Emergency Department Patients With Syncope?

by Hans Rosenberg | Aug 3, 2020 | Cardiology, Journal Club

Methodology: 4/5 Usefulness: 3/5 Thiruganasambandamoorthy V, et al. Ann Intern Med. 2020 May 19;172(10):648-655. Methods: Prospective cohort study to evaluate whether adding NT-proBNP to the CSRS improves prediction of 30-day SAEs. Findings: Adding NT-proBNP provided...