by Mejbel Alazemi | Mar 12, 2026 | Critical Care, Featured, Grand Round Summaries, Infectious Disease, Resuscitation
Antimicrobial stewardship (AMS) is about using the right antibiotic, only when needed, and choosing the appropriate dose, route, and duration. The goal is to treat infections effectively while reducing harm, both to the individual and to the healthcare system. It’s...
by Mathieu McKinnon, Jeff Perry, Shahbaz Syed | Mar 3, 2026 | Featured, Journal Club
Methodology: 4/5 Usefulness: 4/5 N Engl J Med. 2025 Dec 9. doi: 10.1056/NEJMoa2511420. Question and Methods: This multi-center, open label RCT of 2359 patients compared 28-day mortality in patients randomized to receiving ketamine or etomidate for their sedation prior...
by Daniel Czikk, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Dec 15, 2025 | Featured, Journal Club, Neurology
Methodology: 4/5 Usefulness: 4/5 Qiu Z, et al. N Engl J Med. 2025 Jul 10;393(2):139-150. doi: 10.1056/NEJMoa2503867. Question and Methods: This multi-center, open-label RCT of 550 patients in China with acute ischemic stroke due to large vessel occlusion presenting...
by Amanda Mattice, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Dec 8, 2025 | Journal Club, Urology
Methodology: 4/5 Usefulness: 3.5/5 Toumia M, et al. Ann Emerg Med. 2024 Dec;84(6):670-677. doi: 10.1016/j.annemergmed.2024.06.015. Question and Methods: This double-blinded RCT studied whether using adjuncts including MgSO4 and lidocaine are more effective than NSAID...
by Maria Berliant, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Dec 1, 2025 | Full Article, Gastroenterology, Journal Club, Toxicology
Methodology: 3.5/5 Usefulness: 4/5 Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Question and Methods: This multicentre unblinded RCT with 204 patients assessed non-inferiority of a 12-hour NAC protocol for single non-massive...
