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Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta-analysis

Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta-analysis

by Caroline Gregory, Hans Rosenberg, Ian Stiell | Jun 23, 2025 | Full Article, Journal Club, Neurology

Methodology: 4/5 Usefulness: 2/5 Lee CM, et al. Acad Emerg Med. 2024 May;31(5):515-524.  Question and Methods: This is a systematic review and meta-analysis comparing the safety and efficacy of phenobarbital to benzodiazepines for the treatment of alcohol withdrawal...
Managing Complications of Acute Stroke Therapy

Managing Complications of Acute Stroke Therapy

by Emma Ferguson, Lucy Karp | Sep 1, 2022 | Featured, Neurology, Neurosurgery

Acute stroke care is integrated into emergency medicine in many emergency departments across Canada. Whether you are involved in acute stroke care through consultation with neurology or through tele-stroke, understanding the complications of acute stroke therapy and...
CNS Compartment Syndrome: Cerebral Venous Thrombosis

CNS Compartment Syndrome: Cerebral Venous Thrombosis

by Evelyn Tran, Alie Wudwud | Feb 18, 2021 | Featured, Grand Round Summaries, Radiology

Cerebral venous thrombosis (CVT) is a thrombotic disease of the cerebral veins and major dural sinuses. It is a rare kind of venous thromboembolism and can also be thought of as a type of stroke. CVT accounts for 0.5-1% of stroke cases. The annual incidence is 0.2 –...
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus

Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus

by Hans Rosenberg | Mar 2, 2020 | Journal Club, Neurology, Pediatrics

Methodology Score: 4/5 Usefulness Score: 3.5/5 Kapur J et al. N Engl J Med. 2019 Nov 28;381(22):2103-2113.  Question and Methods: A multicenter, randomized, blinded, comparative-effectiveness trial to determine the efficacy and safety of fosphenytoin, valproic acid...
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial

by Hans Rosenberg | Jan 27, 2020 | Full Article, Journal Club, Pediatrics

Methodology: 4/5 Usefulness: 4/5 Lyttle MD, et al. Lancet. 2019 May 25;393(10186):2125-2134. Question and Methods: Eclipse was an open label RCT that evaluated time to seizure cessation in pediatric SE between Keppra and Dilantin Findings: They found that Keppra was...
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