Stroke Archives

Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study

by Mathieu McKinnon, Hans Rosenberg, Jeff Perry | Aug 25, 2025 | Journal Club, Neurology, Pre-Hospital

Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X. Question and Methods: Double-blind, placebo-controlled RCT to determine if prehospital administration of nerinetide for suspected acute...

Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion

by Sandrine Pageau, Hans Rosenberg, Krishan Yadav | Apr 14, 2025 | Featured, Journal Club, Neurology

Methodology: 5/5 Usefulness: 4/5 Goyal M, et al. N Engl J Med. 2025 Feb 5. doi: 10.1056/NEJMoa2411668. Question and Methods: This multi-center, open label RCT of 530 patients presenting with medium-sized vessel stroke within 12h of last seen well compared functional...

Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion

by Maria Berliant, Hans Rosenberg, Christian Vaillancourt | May 6, 2024 | Featured, Full Article, Journal Club, Neurology

Methodology: 4/5 Usefulness: 3/5 Zi W, et al. N Engl J Med. 2023 Jun 1;388(22):2025-2036. Editorial: Expanding Treatment for Acute Ischemic Stroke beyond Revascularization. Question and Methods: This multi-centre, triple-blind, double dummy RCT in China aimed to...

Posterior Circulation Strokes

by Kathleen O'Connell | Mar 14, 2024 | Critical Care, Featured, Grand Round Summaries, Neurology, Recently Featured, Resuscitation

Posterior circulation ischemia accounts for approximately 20-25% of all ischemic strokes and is a significant cause of patient disability. The diagnosis can be extremely challenging as findings are often not typically focal. Posterior strokes are misdiagnosed more...

Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial

by Pascale King, Hans Rosenberg, Christian Vaillancourt | Jan 2, 2024 | Critical Care, Full Article, Journal Club, Neurology

Methodology: 4/5 Usefulness: 2/5 Liu L, et al. BMJ. 2023 Oct 9;383:e076448. Question: Do early vs delayed blood pressure management in patients with mild-moderate acute ischemic strokes decrease death or dependency at 90 days? Methods: Randomization to early (24 hrs)...