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Thrombolytics redux! A rebuttal

Thrombolytics redux! A rebuttal

by Doran Drew | Jun 8, 2021 | Commentary, Critical Care, Grand Round Summaries, Journal Club, Resuscitation

Hey everyone! Buckle up. This is a long one. To provide context, I recently presented a 2-part blog post regarding thrombolytics in acute ischemic stroke. In these posts I explored the foundational literature for this tPA, as well as some of the common controversies I...
Thrombolytic Therapy: A Stroke of Luck? Part 2

Thrombolytic Therapy: A Stroke of Luck? Part 2

by Doran Drew, Josee Malette | May 27, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis

Addressing the Controversies Around Thrombolytic Therapy (tPA) In our previous blog post, we reviewed the formative literature supporting the currently used tPA time window. The figure below highlights a summary of the time windows investigated within each study and...
Thrombolytic Therapy: A Stroke of Luck? Part 1

Thrombolytic Therapy: A Stroke of Luck? Part 1

by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis

Review of the formative literature of our current tPA time window in Acute Ischemic Stroke  After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

by Hans Rosenberg | Mar 22, 2021 | Journal Club, Neurology

Methodology: 4/5 Usefulness: 3.5/5 Thomalla G, et al. Lancet. 2020 Nov 14;396(10262):1574-1584 Question and Methods: The authors evaluated the role of perfusion-imaging facilitated thrombolysis in strokes of unknown duration by way of a systematic review and...
Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.

Ticagrelor and Aspirin or Aspirin Alone in Acute Ischemic Stroke or TIA.

by Hans Rosenberg | Nov 9, 2020 | Journal Club, Neurology

Methodology: 2/5 Usefulness: 2/5 Johnston SC, et al. N Engl J Med. 2020 Jul 16;383(3):207-217. Question and Methods: Multicentre, double-blind RCT of ASA vs Ticagrelor-ASA among 11016 patients with high-risk TIA or minor stroke for prevention of stroke/death within 30...
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