by Hans Rosenberg | Nov 7, 2021 | Featured, Journal Club, Neurology
Methodology: 2.5 5 Usefulness: 2.5/5 Grotta JC, et al. N Engl J Med. 2021 Sep 9;385(11):971-981. doi: 10.1056/NEJMoa2103879. Question and Methods: This study investigated if mobile stroke units (MSU) alter outcomes when compared to standard management by emergency...
by Hans Rosenberg | Oct 4, 2021 | Featured, Journal Club, Neurology
Methodology: 4/5 Usefulness: 4/5 Perry JJ, et al. BMJ. 2021 Feb 4;372:n49. doi: 10.1136/bmj.n49. Question and methods: This multicenter prospective cohort study validates the Canadian TIA Score and compares it to the ABCD2 and ABCD2i score to identify risk...
by Doran Drew | Jun 8, 2021 | Commentary, Critical Care, Grand Round Summaries, Journal Club, Resuscitation
Hey everyone! Buckle up. This is a long one. To provide context, I recently presented a 2-part blog post regarding thrombolytics in acute ischemic stroke. In these posts I explored the foundational literature for this tPA, as well as some of the common controversies I...
by Doran Drew, Josee Malette | May 27, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Addressing the Controversies Around Thrombolytic Therapy (tPA) In our previous blog post, we reviewed the formative literature supporting the currently used tPA time window. The figure below highlights a summary of the time windows investigated within each study and...
by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Review of the formative literature of our current tPA time window in Acute Ischemic Stroke After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...