by Meehan Andrew, Venkatesh Thiruganasambandamoorthy | May 25, 2026 | Journal Club, Neurology
Tenecteplase versus standard medical treatment for basilar artery occlusion within 24 h (TRACE-5): a multicentre, prospective, randomised, open-label, blinded-endpoint, superiority, phase 3 trial Xiong Y, Et al. Lancet. 2026 Feb 21;407(10530):763-772. doi:...
by Daniel Czikk, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Dec 15, 2025 | Featured, Journal Club, Neurology
Methodology: 4/5 Usefulness: 4/5 Qiu Z, et al. N Engl J Med. 2025 Jul 10;393(2):139-150. doi: 10.1056/NEJMoa2503867. Question and Methods: This multi-center, open-label RCT of 550 patients in China with acute ischemic stroke due to large vessel occlusion presenting...
by Faran Khalid, Hans Rosenberg, Ian Stiell | Nov 3, 2025 | Full Article, Journal Club, Neurology
Methodology: 3.5/5 Usefulness: 3.5/5 Alexandrov AW, et al. JAMA Neurol. 2025 Sep 1;82(9):905-914. doi: 10.1001/jamaneurol.2025.2253. Question and Methods: Authors aimed to determine if 0° head positioning reduces neurological deterioration and mortality in stroke...
by Kaitlin Endres, Hans Rosenberg, Ian Stiell | Oct 22, 2025 | Journal Club, Neurology
Methodology: 4.5/5 Usefulness: 4/5 Miao Z, et al. JAMA. 2025 Aug 19;334(7):582-591. doi: 10.1001/jama.2025.10800. Question and Methods: To compare clinical outcomes in patients with acute LVO for those who received intra-arterial tenecteplase after successful...
by Mathieu McKinnon, Hans Rosenberg, Jeff Perry | Aug 25, 2025 | Journal Club, Neurology, Pre-Hospital
Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X. Question and Methods: Double-blind, placebo-controlled RCT to determine if prehospital administration of nerinetide for suspected acute...
