by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Review of the formative literature of our current tPA time window in Acute Ischemic Stroke After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...
by Hans Rosenberg | Mar 22, 2021 | Journal Club, Neurology
Methodology: 4/5 Usefulness: 3.5/5 Thomalla G, et al. Lancet. 2020 Nov 14;396(10262):1574-1584 Question and Methods: The authors evaluated the role of perfusion-imaging facilitated thrombolysis in strokes of unknown duration by way of a systematic review and...
by Hans Rosenberg | Jul 29, 2019 | Journal Club, Neurology
Journal Club Summary Methodology: 3.5/5 Usefulness: 2.5/5 Ma H, et al N Engl J Med. 2019 May 9;380(19):1795-1803 Editorial: Image-Guided Intravenous Alteplase for Stroke – Shattering a Time Window. Question and Methods: This was an international, multicenter,...
by Hans Rosenberg | Nov 26, 2018 | Journal Club, Neurology
Journal Club Summary Methodology Score: 4/5 Usefulness Score: 5/5 Nogueira RG, et al. N Engl J Med. 2018 Jan 4;378(1):11-21 Editorial: A New DAWN for Imaging-Based Selection in the Treatment of Acute Stroke. Questions and Methods: DAWN was an open-label multi-centre...
by emottawa | May 25, 2015 | Journal Club
Journal Club Summary Methodology Score: 4/5 Usefulness Score: 3/5 Berkhemer OA et al for the MR CLEAN Investigators.N Engl J Med. 2015 Jan;372(1):11-20. Full Article This pragmatic, multicentre, block-randomized RCT in the Netherlands found...
