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Thrombolytic Therapy: A Stroke of Luck? Part 1

Thrombolytic Therapy: A Stroke of Luck? Part 1

by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis

Review of the formative literature of our current tPA time window in Acute Ischemic Stroke  After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

by Hans Rosenberg | Mar 22, 2021 | Journal Club, Neurology

Methodology: 4/5 Usefulness: 3.5/5 Thomalla G, et al. Lancet. 2020 Nov 14;396(10262):1574-1584 Question and Methods: The authors evaluated the role of perfusion-imaging facilitated thrombolysis in strokes of unknown duration by way of a systematic review and...
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

by Hans Rosenberg | Jul 29, 2019 | Journal Club, Neurology

Journal Club Summary Methodology: 3.5/5 Usefulness: 2.5/5 Ma H, et al N Engl J Med. 2019 May 9;380(19):1795-1803 Editorial: Image-Guided Intravenous Alteplase for Stroke – Shattering a Time Window.  Question and Methods: This was an international, multicenter,...
Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

by Hans Rosenberg | Nov 26, 2018 | Journal Club, Neurology

Journal Club Summary Methodology Score: 4/5 Usefulness Score: 5/5 Nogueira RG, et al. N Engl J Med. 2018 Jan 4;378(1):11-21 Editorial: A New DAWN for Imaging-Based Selection in the Treatment of Acute Stroke.  Questions and Methods: DAWN was an open-label multi-centre...

A randomized trial of intraarterial treatment for acute ischemic stroke

by emottawa | May 25, 2015 | Journal Club

Journal Club Summary Methodology Score: 4/5                    Usefulness Score:  3/5   Berkhemer OA et al for the MR CLEAN Investigators.N Engl J Med. 2015 Jan;372(1):11-20. Full Article   This pragmatic, multicentre, block-randomized RCT in the Netherlands found...
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