by Mathieu McKinnon, Hans Rosenberg, Jeff Perry | Aug 25, 2025 | Journal Club, Neurology, Pre-Hospital
Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X. Question and Methods: Double-blind, placebo-controlled RCT to determine if prehospital administration of nerinetide for suspected acute...
by Talal Alkhaldi | Jul 3, 2025 | ENT, Featured, Grand Round Summaries, Neurology, Ophthalmology
Imagine waking up one day, and the world around you is no longer as you’ve always seen it. The numbers on your alarm clock blur into nothingness, or half of your vision seems to have vanished altogether. Panic sets in as you make your way to the emergency department....
by Caroline Gregory, Hans Rosenberg, Ian Stiell | Jun 23, 2025 | Full Article, Journal Club, Neurology
Methodology: 4/5 Usefulness: 2/5 Lee CM, et al. Acad Emerg Med. 2024 May;31(5):515-524. Question and Methods: This is a systematic review and meta-analysis comparing the safety and efficacy of phenobarbital to benzodiazepines for the treatment of alcohol withdrawal...
by Sandrine Pageau, Hans Rosenberg, Krishan Yadav | Apr 14, 2025 | Featured, Journal Club, Neurology
Methodology: 5/5 Usefulness: 4/5 Goyal M, et al. N Engl J Med. 2025 Feb 5. doi: 10.1056/NEJMoa2411668. Question and Methods: This multi-center, open label RCT of 530 patients presenting with medium-sized vessel stroke within 12h of last seen well compared functional...
by Courtney Price, Hans Rosenberg, Krishan Yadav | Jan 27, 2025 | Full Article, Journal Club, Neurology, Neurosurgery, Thrombosis
Methodology 3/5 Usefulness 3/5 Connolly SJ, et al. N Engl J Med. 2024 May 16;390(19):1745-1755. Editorial: Reversing Oral Anticoagulation in Intracerebral Hemorrhage. Question and Methods: This unblinded, multicentre randomized controlled trial studied whether...
by Eusang Ahn | Sep 26, 2024 | Commentary, Critical Care, Featured, Neurology, pharmacology, Resuscitation
I wrote this piece because understanding diseases by framing them as high or low levels of dopamine, acetylcholine, glutamate, or GABA has significantly improved my grasp of their pathophysiology and treatment strategies. Too often, medicine is taught as isolated...
by Josee Malette, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | May 20, 2024 | Full Article, Journal Club, Neurology
Methodology: 3/5 Usefulness: 2/5 Fischer U, et al. N Engl J Med. 2023 Jun 29;388(26):2411-2421. Question and Methods: RCT at 103 sites to compare outcomes at 30 days for early versus late DOAC initiation among patients with ischemic stroke and atrial fibrillation....
by Maria Berliant, Hans Rosenberg, Christian Vaillancourt | May 6, 2024 | Featured, Full Article, Journal Club, Neurology
Methodology: 4/5 Usefulness: 3/5 Zi W, et al. N Engl J Med. 2023 Jun 1;388(22):2025-2036. Editorial: Expanding Treatment for Acute Ischemic Stroke beyond Revascularization. Question and Methods: This multi-centre, triple-blind, double dummy RCT in China aimed to...
by Maria Berliant | Apr 11, 2024 | Featured, Grand Round Summaries, Neurology, psychiatry, Recently Featured
Note: This grand rounds presentation and summary had contributions from Dr. Anne-Marie Abe, a neuropsychiatrist specializing in functional neurological disorders in Ottawa. Patients living with functional neurologic disorders (FND) have been deeply stigmatized...
by Kathleen O'Connell | Mar 14, 2024 | Critical Care, Featured, Grand Round Summaries, Neurology, Recently Featured, Resuscitation
Posterior circulation ischemia accounts for approximately 20-25% of all ischemic strokes and is a significant cause of patient disability. The diagnosis can be extremely challenging as findings are often not typically focal. Posterior strokes are misdiagnosed more...
