We are excited to introduce the Sixth edition of The Ottawa Handbook of Emergency Medicine. Your bedside guide for approaches to various Emergency Medicine presentations.
Highlights of the Sixth edition include the addition of: Oncologic emergencies, approach to the pregnant patient, geriatrics and more!
Intravenous Subdissociative-Dose Ketamine Versus Morphine for Analgesia in the Emergency Department: A Randomized Controlled Trial
Journal Club Summary Methodology Score: 3.5/5 Usefulness Score: 2/5 Motov S, Rockoff B, Cohen V, et al. Ann Emerg Med. 2015 Mar 26. pii: S0196-0644(15)00191-2. Abstract Link This prospective, RCT found sub-dissociative ketamine (0.3mg/kg) and...
Randomized assessment of rapid endovascular treatment of ischemic stroke
Journal Club Summary Methodology Score: 4/5 Usefulness Score: 4/5 Goyal M, Demchuk AM, Menon BK, et al. N Engl J Med. 2015 Mar 12;372(11):1019-30 Full Article This multi-centre open label RCT compared endovascular treatment +/- tPA vs. standard...
Emerging drugs of abuse!
This isn't your parent's marijuana, thats for sure. As we continue to develop as a species, individuals are continuously attempting to develop newer and greater drug highs. As a result, the toxicologic world is continuously expanding, and in Emergency Medicine...
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
Journal Club Summary Methodology Score: 4/5 Usefulness Score: 3.5/5 Holcomb JB, Tilley BC, Baraniuk S, et al. JAMA. 2015 Feb 3;313(5):471-82. Full Article This prospective multicenter randomized control trial found that there was no statistically...
Differentiation between traumatic tap and aneurysmal subarachnoid hemorrhage: prospective cohort study
Journal Club Summary Methodology Score: 4/5 Usefulness Score: 4.5/5 Perry, Jeffrey J. et al. Full Article This prospective observational cohort study identified a cutoff as 2000 x 106/L RBC on the final CSF tube and no xanthochromia as a...
A Randomized Trial of Icatibant in ACE-Inhibitor–Induced Angioedema
Journal Club Summary Methodology Score: 1.5/5 Usefulness Score: 1/5 Baş M, Greve J, Stelter K, et al. N Engl J Med. 2015 Jan 29;372(5):418-25 Full Article This small phase 2, multicenter, double blind randomized trial of 30 ED patients found a...
Association of Pyuria and Clinical Characteristics With the Presence of Urinary Tract Infection Among Patients With Acute Nephrolithiasis
Journal Club Summary Methodology Score: 2.5/5 Usefulness Score: 2.5/5 Abrahamian FM, Krishnadasan A, Mower WR, et al. Ann Emerg Med. 2013 Nov;62(5):526-33. Abstract Link Pyuria alone cannot be used to determine if UTI is present in patients with...
Opioid Alternatives in Acute Severe Pain
The ED patient in acute severe pain can be a challenge to treat. Even when we prescribe opioids appropriately (which is less often than you think), patient contraindications, side effects, and a poor analgesic response may limit their use. There is lots of new...
Intensive blood pressure reduction in acute intracerebral haemorrhage: a meta-analysis
Journal Club Summary Methodology Score: 3/5 Usefulness Score: 3/5 Tsivgoulis G, Katsanos AH, Butcher KS, et al. Neurology. 2014 Oct 21;83(17):1523-9 Abstract Link This systematic review and meta-analysis of 4 RCTs found that mortality rates...
Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.
Journal Club Summary Methodology Score: 3/5 Usefulness Score: 2/5 Blum CA, Nigro N Briel M, et al. Lancet. 2015 Jan 16. pii: S0140-6736(14)62447-8. Abstract Link This randomized, double-blinded, placebo-controlled trial demonstrated an improved time to ‘clinical...


