PEAChY-O: Pharmacological Emergency Management of Agitation in Children and Young People: A Randomized Controlled Trial of Oral Medication

PEAChY-O: Pharmacological Emergency Management of Agitation in Children and Young People: A Randomized Controlled Trial of Oral Medication

by , , | Sep 22, 2025 | Full Article, Journal Club, mental health, Pediatrics, psychiatry

Methodology: 3.5/5 Usefulness: 3/5 Bourke EM, et al. Ann Emerg Med. 2025 Jul;86(1):1-11. doi: 10.1016/j.annemergmed.2025.01.007.  Question and Methods: In this randomized, open-label, multicentre trial, the authors investigated whether oral olanzapine was more...
Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial

Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial

by , , | Jul 14, 2025 | Cardiology, Full Article, Journal Club

Methodology: 4/5 Usefulness: 3.5/5 Miller J, et al. Ann Emerg Med. 2024 Oct;84(4):399-408. doi: 10.1016/j.annemergmed.2024.04.024.  Question and Methods: The Authors assessed whether a 0/1-hour high-sensitivity troponin protocol increased safe ED discharges compared...
High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial

High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial

by , , | Jun 2, 2025 | Critical Care, Full Article, Respirology

Methodology: 3.5/5 Usefulness: 3/5 RENOVATE Investigators and the BRICNet Authors; et al. JAMA. 2025 Mar 11;333(10):875-890. doi: 10.1001/jama.2024.26244. Question and methods: This multicentre, adaptive, RCT aimed to demonstrate noninferiority of HFNO vs NIV in...
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial

Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial

by , , | Apr 28, 2025 | Airway, Critical Care, Full Article, Journal Club, Respirology

Methodology: 3/5 Usefulness: 3/5 Luo Z,  et al. JAMA. 2024;332(20):1709–1722. doi:10.1001/jama.2024.15815 Question and Methods: Multi-centre, randomized control trial to determine whether a high-intensity NIPPV strategy reduces the need for intubation in AECOPD...
Failure rate of D-dimer testing in patients with high clinical probability of pulmonary embolism: Ancillary analysis of three European studies

Failure rate of D-dimer testing in patients with high clinical probability of pulmonary embolism: Ancillary analysis of three European studies

by , , | Apr 7, 2025 | Featured, Full Article, Journal Club, Thrombosis

Methodology: 2.5/5 Usefulness: 2/5 Bannelier H, et al. Acad Emerg Med. 2025 Feb;32(2):116-122. doi: 10.1111/acem.15032.  Editorial: D-dimer in high-risk pulmonary embolism workup. Question and Methods: The authors performed a post-hoc analysis of three European...