dexamethasone Archives

Randomized Trial Comparing Low- vs High-Dose IV Dexamethasone for Patients With Moderate to Severe Migraine

by Amanda Mattice, Hans Rosenberg, Jeff Perry | Jan 22, 2024 | Journal Club, Neurology

Methodology: 3.5/5 Usefulness: 4/5 Friedman BW, et al. Neurology. 2023 Oct 3;101(14):e1448-e1454. Question and Methods: This double-blinded RCT of 209 patients presenting to the ED with moderate to severe migraines compared high- to low- dose dexamethasone (16 mg vs...

Dexamethasone and ketorolac compare with ketorolac alone in acute renal colic: A randomized clinical trial

by Marissa Ukos, Hans Rosenberg, Venkatesh Thiruganasambandamoorthy | Mar 7, 2023 | Addictions, Chronic Pain, Full Article, Journal Club, Urology

Methodology: 2.5/5 Usefulness: 2.5/5 Razi A, et al. Am J Emerg Med. 2022 Aug;58:245-250. Question and Methods: This single-center, RCT of 120 patients with acute renal colic compared pain control and antiemetic use with dexamethasone + ketorolac compared to...

Effect of 12 mg vs 6 mg of Dexamethasone on the Number of Days Alive Without Life Support in Adults With COVID-19 and Severe Hypoxemia: The COVID STEROID 2 Randomized Trial

by Kevin Durr, Jeff Perry, Hans Rosenberg | Jan 24, 2022 | Full Article, Infectious Disease, Journal Club

Methodology: 3.5/5 Usefulness: 3.5/5 COVID STEROID 2 Trial Group, Munch MW, et al. JAMA. 2021 Nov 9;326(18):1807-1817. doi: 10.1001/jama.2021.18295. Question and Methods: This blinded randomized clinical trial compared the effects of 12 mg daily relative to 6 mg daily...

A Randomized Controlled Noninferiority Trial of Single Dose of Oral Dexamethasone Versus 5 Days of Oral Prednisone in Acute Adult Asthma

by emottawa | Jun 12, 2017 | Journal Club

Journal Clubs Summary Methodology Score: 3/5 Usefulness Score: 3.5/5 Rehrer MW, et al. Ann Emerg Med. 2016 Nov;68(5):608-613. Abstract Link This single centre, randomized, triple-blinded, control trial did not demonstrate noninferiority of a single dose of...

Parenteral dexamethasone for acute severe migraine headache: meta-analysis of randomised controlled trials for preventing recurrence

by EMOttawa | Sep 3, 2013 | Journal Club, landmark

Journal Club Summary Landmark Article Series Methodology Score: 4.5/5 Usefulness Score: 4.5/5 Colman I, Friedman BW, Brown MD, Innes GD, Grafstein E, Roberts TE, Rowe BH. BMJ. 2008 Jun 14;336(7657):1359-61 Article Link In this well performed meta-analysis, a...