by Eusang Ahn, Hans Rosenberg | Jan 10, 2022 | Featured, Full Article, Journal Club, Pediatrics
Methodology: 4/5 Usefulness: 2/5 Desjardins MP, et al. CJEM. 2021 Sep;23(5):655-662. doi: 10.1007/s43678-021-00130-x. Epub 2021 May 26. Question and Methods: This double-blinded RCT compares analgesic efficacy of oral sucrose versus placebo in bladder catheterization...
by Krishan Yadav | Jan 6, 2022 | Commentary, Featured, Journal Club
Sotrovimab Sotrovimab is a monoclonal antibody that neutralizes sarbecoviruses (respiratory viruses detected by PCR on oral/nasal swabs or from bronchial/lung/respiratory tract specimens). This antibody was first isolated from a patient with SARS-CoV-1 (the virus...
by Elyssia Adamo, Hans Rosenberg | Dec 30, 2021 | Full Article, Journal Club, mental health, psychiatry, Toxicology
Methodology: 3.5/5 Usefulness: 3.5/5 Barbic D, et al. Ann Emerg Med. 2021 Aug 2:S0196-0644(21)00433-9. Question and Methods: Randomized, single center, blinded clinical trial comparing the rapidity of onset, level of sedation and adverse effect profile of Ketamine...
by Hans Rosenberg | Dec 13, 2021 | Cardiology, Critical Care, Journal Club, landmark, Resuscitation
Methodology: 5/5 Usefulness: 5/5 Dankiewicz J, et al. N Engl J Med. 2021 Jun 17;384(24):2283-2294. Question and Methods: Open-label multicentre randomized controlled trial to determine whether targeted hypothermia reduces mortality compared to targeted normothermia in...
by Kate O'Connell, Hans Rosenberg | Dec 6, 2021 | Cardiology, Critical Care, Journal Club
Methodology: 3.5/5 Usefulness: 3.5/5 Mathew R, et al. N Engl J Med. 2021 Aug 5;385(6):516-525. Question and Methods: The authors performed a double-blinded RCT to determine if milrinone was superior to dobutamine for the treatment of cardiogenic shock in the ICU. ...
by Maeghan Fu, Hans Rosenberg | Nov 29, 2021 | Journal Club
Methodology: 2.5/5 Usefulness: 3/5 Lin J, et al. Am J Emerg Med. 2021 Jun;44:306-311. Question and Methods: Open-label prospective study comparing the efficacy and safety of ketamine versus haloperidol plus lorazepam in the treatment of acute combative agitation in...
by Hans Rosenberg | Nov 7, 2021 | Featured, Journal Club, Neurology
Methodology: 2.5 5 Usefulness: 2.5/5 Grotta JC, et al. N Engl J Med. 2021 Sep 9;385(11):971-981. doi: 10.1056/NEJMoa2103879. Question and Methods: This study investigated if mobile stroke units (MSU) alter outcomes when compared to standard management by emergency...
by Chirag Bhat, Hans Rosenberg | Nov 2, 2021 | cardiac arrest, Cardiology, Critical Care, Journal Club
Methodology: 4/5 Usefulness: 4/5 Desch S, et al. N Engl J Med. 2021 Aug 29. doi: 10.1056/NEJMoa2101909. Question and Methods: This multi-center, open label RCT of 558 patients with OHCA without ST elevation on their ECG compared 30-day all-cause mortality...
by Darren Wong, Hans Rosenberg | Oct 25, 2021 | Full Article, Infectious Disease, Journal Club
Methodology: 1/5 Usefulness: 1/5 von Dach E, et al. JAMA. 2020 Jun 2;323(21):2160-2169. doi: 10.1001/jama.2020.6348. Question and Methods: In a multi-center, noninferiority, randomized, double-blinded clinical trial, the authors compared the rates of...
by Hans Rosenberg | Oct 11, 2021 | Critical Care, Journal Club, Respirology
Methodology: 4/5 Usefulness: 3/5 Schjørring OL, et al. N Engl J Med. 2021 Apr 8;384(14):1301-1311. doi: 10.1056/NEJMoa2032510. Question and Methods: Can a lower PaO2 target (i.e., 60mmHg) compared to higher PaO2 target (i.e., 90mmHg) decrease all cause 90...
