Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study

Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study

Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X.  Question and Methods: Double-blind, placebo-controlled RCT to determine if prehospital administration of nerinetide for suspected acute...
Ketamine Compared With Morphine for Out-of-Hospital Analgesia for Patients With Traumatic Pain: A Randomized Clinical Trial

Ketamine Compared With Morphine for Out-of-Hospital Analgesia for Patients With Traumatic Pain: A Randomized Clinical Trial

Methodology: 3/5 Usefulness: 1.5/5 Le Cornec C, e al. JAMA Netw Open. 2024 Jan 2;7(1):e2352844.  Question and Methods: This was a multicenter, single-blind, noninferiority RCT, to assess the noninferiority of intravenous ketamine vs intravenous morphine for pain...
Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial

Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial

Methodology: 4/5 Usefulness: 3/5 Crombie N, et al. Lancet Haematol. 2022 Apr;9(4):e250-e261.  Question and Methods: Multicenter RCT investigating prehospital resuscitation using PRBC and plasma vs normal saline to improve tissue perfusion or mortality in adult trauma...