by Doran Drew, Josee Malette, Kate O'Connell | May 20, 2021 | Featured, Grand Round Summaries, Neurology, Thrombosis
Review of the formative literature of our current tPA time window in Acute Ischemic Stroke After numerous case series and smaller prospective studies suggesting benefit for thrombolytic therapy (tPA), the early 90s ushered in the era of thrombolytic RCTs for acute...
by Hans Rosenberg | May 10, 2021 | ENT, Featured, Journal Club, Thrombosis
Methodology: 3/5 Usefulness: 3/5 Reuben A, et al. Ann Emerg Med. 2021 Feb 18:S0196-0644(20)31461-X. Question and Methods: This was a double-blind, randomized controlled trial comparing topical tranexamic acid to placebo in patients presenting to the ED with epistaxis...
by Jim Yang, Kaitlin Endres, Josee Malette | Nov 19, 2020 | Critical Care, Featured, Grand Round Summaries, Medical Education, Thrombosis
Pulmonary embolism is often a nebulous diagnosis with various nuances. COMMON: They affect 25-100 people per 100,000, or approximately 30,000 Canadians every year Potentially FATAL: 3rd most deadly cardiovascular disease, after Heart Attack and Stroke Associated with...
by Hans Rosenberg | Nov 16, 2020 | Critical Care, Journal Club, Resuscitation, Thrombosis, Trauma
Methodology: 4/5 Usefulness: 3.5/5 Baksaas-Aasen K, et al. Intensive Care Med. 2020 Oct 13. doi: 10.1007/s00134-020-06266-1. Question and Methods: Pragmatic, European, multi-center RCT comparing outcomes in trauma patients who received empiric massive transfusion...
by Hans Rosenberg | Mar 23, 2020 | Cardiology, Featured, Journal Club, Thrombosis
Methodology Score: 4/5 Usefulness Score: 4/5 Schüpke S, et al N Engl J Med. 2019 Oct 17;381(16):1524-1534. Editorial: Ticagrelor or Prasugrel in Acute Coronary Syndromes – The Winner Takes It All? Question and Methods: This open-label multicenter trial was the...
by Hans Rosenberg | Feb 10, 2020 | Journal Club, landmark, Thrombosis
Methodology Score: 4/5 Usefulness Score: 4.5/5 Kearon C, et al. N Engl J Med. 2019 Nov 28;381(22):2125-2134 Question and Methods: the authors sought to demonstrate safety using a d-dimer cut-off of 1000ng/mL for low pre-test probability patients & a cut-off of...
by Hans Rosenberg | Aug 19, 2019 | Journal Club, OBGYN, Thrombosis
Journal Club Summary Methodology Score: 4.5/5 Usefulness Score: 4.5 /5 van der Pol LM, et al. N Engl J Med. 2019 Mar 21;380(12):1139-1149 Question and Methods: Using a prospective cohort study of 510 pregnant women, the authors were trying to see whether an algorithm...
by Hans Rosenberg | May 13, 2019 | Journal Club, Thrombosis
Journal Club Summary Methodology: 2.5/5 Usefulness: 2/5 Connolly SJ, et al. N Engl J Med. 2019 Feb 7. Question and Methods: This was the first trial looking at clinical outcomes for reversal of factor Xa inhibitor anticoagulation in major bleeding episodes using the...
by Hans Rosenberg | Dec 17, 2018 | Featured, Journal Club, Thrombosis
Journal Club Summary Methodology: 4/5 Usefulness: 4/5 Kent AP, et al. J Am Coll Cardiol. 2018 Jul 17;72(3):255-267 Question and Methods: This was a post hoc analysis of the RE-LY trial examining the risk of NSAID use in patients receiving oral anticoagulation (OAC)...
by Robert Suttie, Matthew Lipinski | Feb 15, 2018 | cardiac arrest, Cardiology, Critical Care, Resuscitation, Thrombosis
There are a few specific arrhythmias that we encounter often in the ED that deserve a little bit more thought. Dr. Matthew Lipinski takes us through a few updates in the area beyond the routine basics. For other Grand Rounds Summaries please see our archives. Chronic...