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Journal Club Summary Methodology Score: 2.5/5               Usefulness Score: 2/5   Schortgen F, et al. Am J Respir Crit Care Med. 2012 May 15;185(10):1088-95 Full Article    This randomized, non-blinded trial found in an ICU population that external cooling in febrile patients with septic shock resulted in a 50% decrease in vasopressorRead More →

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Journal Club Summary Methodology Score: 4.5/5                           Usefulness Score: 4.5/5   Imazio M, et al. ICAP Investigators. N Engl J Med. 2013 Oct 17;369(16):1522-8. Article Link   This multicentre double-blind RCT found that a 3 month course of low-dose colchicine is superior to placebo in reducing recurrence rates after first-episode pericarditis (NNT 4,Read More →

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Journal Club Summary Landmark Series Methodology Score: 4/5                  Usefulness Score: 4/5   Wilkerson RG, Stone MB. Acad Emerg Med. 2010 Jan;17(1):11-7.   Article Link 
 This evidence-based literature review of four prospective observational studies identified that bedside ultrasound had excellent sensitivity (86-98%) especially compared to supine AP xray (28-75%) forRead More →

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Journal Club Summary Methodology Score: 2.5/5               Usefulness Score: 2.5/5   Downie A, et al. BMJ 2013;347:f7095 Article Link   This Cochrane review of the diagnostic accuracy of red flags for fracture or malignancy in patients with low back pain in multiple settings found that corticosteroid use (+LR 4-48.5), severe trauma (+LRRead More →

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Journal Club Summary Landmark Series Methodology Score: 4/5                  Usefulness Score: 4/5   CRASH-2 trial collaborators Lancet. 2010 Jul 3;376(9734):23-32. Article Link This large RCT assessed the effect of early administration of tranexamic acid to trauma patients and revealed statistically significant results in favour of TXA for the reduction of overallRead More →

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Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   Bateman DN, et al. Lancet. 2014 Feb 22;383(9918):697-704 Article Link   This 2×2 factorial, intention to treat, randomized controlled trial of paracetamol overdose showed a modified 12 h NAC protocol vs 20.25h protocol and ondansetron pre-treatment vs placebo causes lessRead More →

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Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   INTERACT2 Investigators. N Engl J Med. 2013 Jun 20;368(25):2355-65.   Article Link   This large multicentre, partially blinded RCT compared aggressively lowering SBP to <140 vs. standard care in acute non-traumatic intracerebral hemorrhage and found no significant difference in ratesRead More →

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Journal Club Summary Methodology Score: 4.5/5                  Usefulness Score: 3.5/5 Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. CMAJ. 2013 Sep 17;185(13):E629-34.   Article Link   This study was a double blind RCT which demonstrated that using topical LET on minor lacerations before wound closure with tissue adhesive, reducedRead More →

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Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 4/5   Blyth L, Atkinson P, Gadd K, Lang E. Acad Emerg Med. 2012 Oct;19(10):1119-26. Article Link   This systematic review of 8 studies found that when transthoracic ultrasound is performed during cardiac arrest, the absence of cardiac activity indicates a lowRead More →

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Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   Morelli A, et al. JAMA. 2013 Oct 23;310(16):1683-91 Article Link   This single centre phase 2B trial randomized septic patients still requiring vasopressors after 24hrs of EGDT to esmolol infusions to a target hear rate of between 85-94 or standardRead More →