
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 4/5 Taccone FS, et al. JAMA. 2024 Nov 19;332(19):1623-1633. Question and Methods: This multicenter, randomized trial aimed to determine... Read more.

Noninvasive Ventilation for Preoxygenation during Emergency Intubation
Methodology: 4/5 Usefulness: 3.5/5 Gibbs KW, et al. N Engl J Med. 2024 Jun 20;390(23):2165-2177. Question and Methods: The PREOXI trial aimed to determine whether... Read more.

PECARN prediction rules for CT imaging of children presenting to the emergency department with blunt abdominal or minor head trauma: a multicentre prospective validation study
Methodology: 3/5 Usefulness: 3/5 Holmes JF, et al. Lancet Child Adolesc Health. 2024 May;8(5):339-347. Question and Methods: This prospective multicenter cohort... Read more.

Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest
Methodology: 4/5 Usefulness: 4/5 Vallentin MF, et al. N Engl J Med. 2024 Oct 31. doi: 10.1056/NEJMoa2407616. Editorial: The Way to a Patient’s Heart –... Read more.

A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest
Methodology: 4/5 Usefulness: 3/5 Couper K, et al. N Engl J Med. 2024 Oct 31:10.1056/NEJMoa2407780. Question and Methods: This multi-center, open label randomized... Read more.

Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion
Methodology: 4/5 Usefulness: 3/5 Zi W, et al. N Engl J Med. 2023 Jun 1;388(22):2025-2036. Editorial: Expanding Treatment for Acute Ischemic Stroke beyond Revascularization.... Read more.

Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease
Methodology: 3/5 Usefulness: 2/5 Ashburn NP, et al. JAMA Cardiol. 2023 Apr 1;8(4):347-356. Editorial: Critical Appraisal of the Negative Predictive Performance... Read more.

Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial
Methodology: 3/5 Usefulness: 3/5 Bandyopadhyay A, et al. Anesth Analg. 2023 May 1;136(5):913-919. Question and Methods: This is the first RCT looking at DSI vs... Read more.

Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial
Methodology: 4/5 Usefulness: 2/5 Liu L, et al. BMJ. 2023 Oct 9;383:e076448. Question: Do early vs delayed blood pressure management in patients with mild-moderate... Read more.

Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trial
Methodology: 4/5 Usefulness: 3/5 Crombie N, et al. Lancet Haematol. 2022 Apr;9(4):e250-e261. Question and Methods: Multicenter RCT investigating prehospital resuscitation... Read more.