Intravenous Tenecteplase before Thrombectomy in Stroke
Methodology: 4/5 Usefulness: 4/5 Qiu Z, et al. N Engl J Med. 2025 Jul 10;393(2):139-150. doi: 10.1056/NEJMoa2503867. Question and Methods: This multi-center, open-label... Read more.
Magnesium Sulfate Versus Lidocaine as an Adjunct for Renal Colic in the Emergency Department: A Randomized, Double-Blind Controlled Trial
Methodology: 4/5 Usefulness: 3.5/5 Toumia M, et al. Ann Emerg Med. 2024 Dec;84(6):670-677. doi: 10.1016/j.annemergmed.2024.06.015. Question and Methods: This double-blinded... Read more.
A non-inferiority randomized controlled trial of a shorter acetylcysteine regimen for paracetamol overdose – the SARPO trial
Methodology: 3.5/5 Usefulness: 4/5 Isbister G, et al. J Hepatol. 2025 Oct;83(4):881-887. doi: 10.1016/j.jhep.2025.05.008. Question and Methods: This multicentre... Read more.
Optimal Head-of-Bed Positioning Before Thrombectomy in Large Vessel Occlusion Stroke: A Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 3.5/5 Alexandrov AW, et al. JAMA Neurol. 2025 Sep 1;82(9):905-914. doi: 10.1001/jamaneurol.2025.2253. Question and Methods: Authors... Read more.
Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy: The ANGEL-TNK Randomized Clinical Trial
Methodology: 4.5/5 Usefulness: 4/5 Miao Z, et al. JAMA. 2025 Aug 19;334(7):582-591. doi: 10.1001/jama.2025.10800. Question and Methods: To compare clinical outcomes... Read more.
Multidose Ondansetron after Emergency Visits in Children with Gastroenteritis
Freedman SB, et al. N Engl J Med. 2025 Jul 17;393(3):255-266. doi: 10.1056/NEJMoa2503596. Methodology: 4.5/5 Usefulness: 4/5 Question and Methods: This multicentre,... Read more.
PEAChY-O: Pharmacological Emergency Management of Agitation in Children and Young People: A Randomized Controlled Trial of Oral Medication
Methodology: 3.5/5 Usefulness: 3/5 Bourke EM, et al. Ann Emerg Med. 2025 Jul;86(1):1-11. doi: 10.1016/j.annemergmed.2025.01.007. Question and Methods: In this... Read more.
Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study
Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X. Question and Methods: Double-blind,... Read more.
Can we avoid casting for suspected scaphoid fractures? A multicenter randomized controlled trial
Methodology: 4/5 Usefulness: 3/5 Cohen A, et al. J Orthop Traumatol. 2025 Mar 5;26(1):14. doi: 10.1186/s10195-025-00822-5. Question and Methods: Authors tested... Read more.
Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial
Methodology: 4/5 Usefulness: 3.5/5 Miller J, et al. Ann Emerg Med. 2024 Oct;84(4):399-408. doi: 10.1016/j.annemergmed.2024.04.024. Question and Methods: The Authors... Read more.