
Multidose Ondansetron after Emergency Visits in Children with Gastroenteritis
Freedman SB, et al. N Engl J Med. 2025 Jul 17;393(3):255-266. doi: 10.1056/NEJMoa2503596. Methodology: 4.5/5 Usefulness: 4/5 Question and Methods: This multicentre,... Read more.

PEAChY-O: Pharmacological Emergency Management of Agitation in Children and Young People: A Randomized Controlled Trial of Oral Medication
Methodology: 3.5/5 Usefulness: 3/5 Bourke EM, et al. Ann Emerg Med. 2025 Jul;86(1):1-11. doi: 10.1016/j.annemergmed.2025.01.007. Question and Methods: In this... Read more.

Efficacy and safety of intravenous nerinetide initiated by paramedics in the field for acute cerebral ischaemia within 3 h of symptom onset (FRONTIER): a phase 2, multicentre, randomised, double-blind, placebo-controlled study
Methodology: 4/5 Usefulness: 4/5 Christenson J, et al. Lancet. 2025 Feb 15;405(10478):571-582. doi: 10.1016/S0140-6736(25)00193-X. Question and Methods: Double-blind,... Read more.

Can we avoid casting for suspected scaphoid fractures? A multicenter randomized controlled trial
Methodology: 4/5 Usefulness: 3/5 Cohen A, et al. J Orthop Traumatol. 2025 Mar 5;26(1):14. doi: 10.1186/s10195-025-00822-5. Question and Methods: Authors tested... Read more.

Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial
Methodology: 4/5 Usefulness: 3.5/5 Miller J, et al. Ann Emerg Med. 2024 Oct;84(4):399-408. doi: 10.1016/j.annemergmed.2024.04.024. Question and Methods: The Authors... Read more.

Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta-analysis
Methodology: 4/5 Usefulness: 2/5 Lee CM, et al. Acad Emerg Med. 2024 May;31(5):515-524. Question and Methods: This is a systematic review and meta-analysis comparing... Read more.

Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up
Methodology: 4/5 Usefulness: 1/5 Thiele H, et al. Lancet. 2024 Sep 14;404(10457):1019-1028. doi: 10.1016/S0140-6736(24)01448-X Question and Methods: Does routine... Read more.

High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 3/5 RENOVATE Investigators and the BRICNet Authors; et al. JAMA. 2025 Mar 11;333(10):875-890. doi: 10.1001/jama.2024.26244. Question... Read more.

Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis
Methodology: 4/5 Usefulness: 3.5/5 Wilson SJ, et al. Ann Emerg Med. 2024 Mar;83(3):235-246. doi: 10.1016/j.annemergmed.2023.09.005. Questions and Method: To determine... Read more.

Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage
Methodology: 4/5 Usefulness: 3/5 English SW, et al. N Engl J Med. 2025 Mar 13;392(11):1079-1088. doi: 10.1056/NEJMoa2410962. Question and Methods: This multicenter... Read more.