Early versus Later Anticoagulation for Stroke with Atrial Fibrillation
Methodology: 3/5 Usefulness: 2/5 Fischer U, et al. N Engl J Med. 2023 Jun 29;388(26):2411-2421. Question and Methods: RCT at 103 sites to compare outcomes at 30... Read more.
Effect of Bougie Use on First-Attempt Success in Tracheal Intubations: A Systematic Review and Meta-Analysis
Methodology: 4/5 Usefulness: 3/5 von Hellmann R, et al. Ann Emerg Med. 2024 Feb;83(2):132-144. Question and Methods: Systematic review of 18 studies (12 RCT) of... Read more.
Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion
Methodology: 4/5 Usefulness: 3/5 Zi W, et al. N Engl J Med. 2023 Jun 1;388(22):2025-2036. Editorial: Expanding Treatment for Acute Ischemic Stroke beyond Revascularization.... Read more.
Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease
Methodology: 3/5 Usefulness: 2/5 Ashburn NP, et al. JAMA Cardiol. 2023 Apr 1;8(4):347-356. Editorial: Critical Appraisal of the Negative Predictive Performance... Read more.
Peri-Intubation Hypoxia After Delayed Versus Rapid Sequence Intubation in Critically Injured Patients on Arrival to Trauma Triage: A Randomized Controlled Trial
Methodology: 3/5 Usefulness: 3/5 Bandyopadhyay A, et al. Anesth Analg. 2023 May 1;136(5):913-919. Question and Methods: This is the first RCT looking at DSI vs... Read more.
Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 3/5 Freund Y, et al. JAMA. 2023 Dec 19;330(23):2267-2274. Question and Methods: Multicenter RCT involving comatose patients with... Read more.
Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial
Methodology: 5/5 Usefulness: 3/5 Patterson T, et al. Lancet. 2023 Oct 14;402(10410):1329-1337. Patients who sustain an out-of-hospital cardiac arrest without signs... Read more.
Extracorporeal Life Support in Infarct-Related Cardiogenic Shock
Methodology: 4/5 Usefulness: 3.5/5 Thiele H, et al. N Engl J Med. 2023 Oct 5;389(14):1286-1297. Editorial: Routine Early ECLS in Infarct-Related Cardiogenic Shock?... Read more.
Randomized Trial Comparing Low- vs High-Dose IV Dexamethasone for Patients With Moderate to Severe Migraine
Methodology: 3.5/5 Usefulness: 4/5 Friedman BW, et al. Neurology. 2023 Oct 3;101(14):e1448-e1454. Question and Methods: This double-blinded RCT of 209 patients... Read more.
Early versus delayed antihypertensive treatment in patients with acute ischaemic stroke: multicentre, open label, randomised, controlled trial
Methodology: 4/5 Usefulness: 2/5 Liu L, et al. BMJ. 2023 Oct 9;383:e076448. Question: Do early vs delayed blood pressure management in patients with mild-moderate... Read more.