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Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   INTERACT2 Investigators. N Engl J Med. 2013 Jun 20;368(25):2355-65.   Article Link   This large multicentre, partially blinded RCT compared aggressively lowering SBP to <140 vs. standard care in acute non-traumatic intracerebral hemorrhage and found no significant difference in ratesRead More →

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Journal Club Summary Methodology Score: 4.5/5                  Usefulness Score: 3.5/5 Harman S, Zemek R, Duncan MJ, Ying Y, Petrcich W. CMAJ. 2013 Sep 17;185(13):E629-34.   Article Link   This study was a double blind RCT which demonstrated that using topical LET on minor lacerations before wound closure with tissue adhesive, reducedRead More →

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Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 4/5   Blyth L, Atkinson P, Gadd K, Lang E. Acad Emerg Med. 2012 Oct;19(10):1119-26. Article Link   This systematic review of 8 studies found that when transthoracic ultrasound is performed during cardiac arrest, the absence of cardiac activity indicates a lowRead More →

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Journal Club Summary Methodology Score: 4/5                  Usefulness Score: 2/5   Morelli A, et al. JAMA. 2013 Oct 23;310(16):1683-91 Article Link   This single centre phase 2B trial randomized septic patients still requiring vasopressors after 24hrs of EGDT to esmolol infusions to a target hear rate of between 85-94 or standardRead More →

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Journal Club Summary Methodology Score: 3/5                  Usefulness Score: 2.5/5   Geersing GJ, et al. BMJ. 2012 Oct 4;345:e6564. Article Link   This was a prospective cohort validation study using the Wells clinical decision rule combined with D-dimer to exclude PE in primary care. The study found in their low riskRead More →

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Journal Club Summary Landmark Article Series Nielsen N, et al.; TTM Trial Investigators. N Engl J Med. 2013 Dec 5;369(23):2197-206.   Methodology Score: 5/5                             Usefulness Score: 5/5   Article Link   In this multicenter, international RCT of 950 unconscious adults after out-of-hospital cardiac arrest, hypothermia at a targeted temperature ofRead More →

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Journal Club Summary Methodology Score: 4 /5                 Usefulness Score: 3.5/5   Wang Y, Johnston SC, Wang Y. N Engl J Med. 2013 Oct 3;369(14):1376-7. Article Link     This multicenter randomized-control trial of 5,100 patients with TIA/minor stroke treated within 24 hours found clopidogrel and aspirin was superior to aspirinRead More →

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Journal Club Summary Methodology Score: 4.5/5              Usefulness Score: 3/5   Dentali F, Riva N, Crowther M, Turpie AG, Lip GY, Ageno W. Circulation. 2012 Nov 13;126(20):2381-91. Article Link   This was a systematic review and meta-analysis of 12 phase II/III RCTs which found that using New Oral Anticoagulants (NOACs: dabigatran,Read More →

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Journal Club Summary Methodology Score: 2/5                  Usefulness Score: 3.5/5 Zahed R, Moharamzadeh P, Alizadeharasi S, Ghasemi A, Saeedi M.Am J Emerg Med.2013 Sep;31(9):1389-92 Abstract Link This single centre, ED based, parallel group randomized control trial found that the topical application of an injectable form of tranexamic acid (TXA) was betterRead More →

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Journal Club Summary Methodology Score: 3.5/5               Usefulness Score: 3.5/5 Quant EC, Jeste SS, Muni RH, Cape AV, Bhussar MK, Peleg AY. BMJ. 2009 Sep 7;339:b3354. doi: 10.1136/bmj.b3354. Article Link This meta-analysis of randomized controlled trials comparing the use of steroids alone vs steroids and antivirals in the treatment of Bell’sRead More →