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Journal Club Summary Methodology Score: 4/5                 Usefulness Score: 4/5 Leuppi JD, et al. JAMA. 2013 Jun 5;309(21):2223-31. Article Link   This multicenter, double blinded trial demonstrated non-inferiority of a 5-day course of 40mg prednisone versus a 14-day course of 40mg prednisone in the treatment of patients admitted to hospital for acuteRead More →

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Journal Club Summary Methodology Score: 3.5/5              Usefulness Score: 2.5/5   Caironi P, Tognoni G, et al. the ALBIOS Study Investigators. N Engl J Med. 2014 Mar 18. Abstract Link   This was an open-label RCT of 1,800 ICU patients with severe sepsis or septic shock, examining whether targeting a certain serum albumin levelRead More →

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Journal Club Summary Methodology Score: 4/5                 Usefulness Score: 2/5 Verhaegen J, Gallos ID, van Mello NM, Abdel-Aziz M, Takwoingi Y, Harb H, Deeks JJ, Mol BW, Coomarasamy A BMJ. 2012 Sep 27;345:e6077 Article Link This thorough and well performed systematic literature review found that a single progesterone test before 14 weeks gestationalRead More →

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Journal Club Summary Methodology Score: 4/5  Usefulness Score:  3.5/5 Aujesky D, et al. Lancet. 2011 Jul 2;378(9785):41-8. Abstract Link   This open label, randomized, un-blinded, multi-centered trial compared inpatient vs. outpatient treatment of low-risk PE showed that outpatient management is non-inferior with respect to endpoints of recurrent VTE, major bleeding, and mortality.Read More →

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Journal Club Summary Methodology Score: 2.5/5               Usefulness Score: 2/5   Schortgen F, et al. Am J Respir Crit Care Med. 2012 May 15;185(10):1088-95 Full Article    This randomized, non-blinded trial found in an ICU population that external cooling in febrile patients with septic shock resulted in a 50% decrease in vasopressorRead More →

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Journal Club Summary Methodology Score: 4.5/5                           Usefulness Score: 4.5/5   Imazio M, et al. ICAP Investigators. N Engl J Med. 2013 Oct 17;369(16):1522-8. Article Link   This multicentre double-blind RCT found that a 3 month course of low-dose colchicine is superior to placebo in reducing recurrence rates after first-episode pericarditis (NNT 4,Read More →

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Journal Club Summary Landmark Series Methodology Score: 4/5                  Usefulness Score: 4/5   Wilkerson RG, Stone MB. Acad Emerg Med. 2010 Jan;17(1):11-7.   Article Link 
 This evidence-based literature review of four prospective observational studies identified that bedside ultrasound had excellent sensitivity (86-98%) especially compared to supine AP xray (28-75%) forRead More →

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Journal Club Summary Methodology Score: 2.5/5               Usefulness Score: 2.5/5   Downie A, et al. BMJ 2013;347:f7095 Article Link   This Cochrane review of the diagnostic accuracy of red flags for fracture or malignancy in patients with low back pain in multiple settings found that corticosteroid use (+LR 4-48.5), severe trauma (+LRRead More →

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Journal Club Summary Landmark Series Methodology Score: 4/5                  Usefulness Score: 4/5   CRASH-2 trial collaborators Lancet. 2010 Jul 3;376(9734):23-32. Article Link This large RCT assessed the effect of early administration of tranexamic acid to trauma patients and revealed statistically significant results in favour of TXA for the reduction of overallRead More →