Phenobarbital treatment of alcohol withdrawal in the emergency department: A systematic review and meta-analysis
Methodology: 4/5 Usefulness: 2/5 Lee CM, et al. Acad Emerg Med. 2024 May;31(5):515-524. Question and Methods: This is a systematic review and meta-analysis comparing... Read more.
Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up
Methodology: 4/5 Usefulness: 1/5 Thiele H, et al. Lancet. 2024 Sep 14;404(10457):1019-1028. doi: 10.1016/S0140-6736(24)01448-X Question and Methods: Does routine... Read more.
High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 3/5 RENOVATE Investigators and the BRICNet Authors; et al. JAMA. 2025 Mar 11;333(10):875-890. doi: 10.1001/jama.2024.26244. Question... Read more.
Test Characteristics of Emergency Medicine-Performed Point-of-Care Ultrasound for the Diagnosis of Acute Cholecystitis: A Systematic Review and Meta-analysis
Methodology: 4/5 Usefulness: 3.5/5 Wilson SJ, et al. Ann Emerg Med. 2024 Mar;83(3):235-246. doi: 10.1016/j.annemergmed.2023.09.005. Questions and Method: To determine... Read more.
Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage
Methodology: 4/5 Usefulness: 3/5 English SW, et al. N Engl J Med. 2025 Mar 13;392(11):1079-1088. doi: 10.1056/NEJMoa2410962. Question and Methods: This multicenter... Read more.
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial
Methodology: 3/5 Usefulness: 3/5 Luo Z, et al. JAMA. 2024;332(20):1709–1722. doi:10.1001/jama.2024.15815 Question and Methods: Multi-centre, randomized control... Read more.
Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion
Methodology: 5/5 Usefulness: 4/5 Goyal M, et al. N Engl J Med. 2025 Feb 5. doi: 10.1056/NEJMoa2411668. Question and Methods: This multi-center, open label RCT... Read more.
Failure rate of D-dimer testing in patients with high clinical probability of pulmonary embolism: Ancillary analysis of three European studies
Methodology: 2.5/5 Usefulness: 2/5 Bannelier H, et al. Acad Emerg Med. 2025 Feb;32(2):116-122. doi: 10.1111/acem.15032. Editorial: D-dimer in high-risk pulmonary... Read more.
Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial
Methodology: 4/5 Usefulness: 2/5 Arleth T, et al. JAMA. 2025;333(6):479–489. doi:10.1001/jama.2024.25786 Question and Methods: This multicentered randomized control... Read more.
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial
Methodology: 3.5/5 Usefulness: 4/5 Taccone FS, et al. JAMA. 2024 Nov 19;332(19):1623-1633. Question and Methods: This multicenter, randomized trial aimed to determine... Read more.